This issue, our fifth, details several lines of inquiry that each reconceptualize some small parcel of our neuroscientific knowledge: from integrating new frameworks with classic theories (“Neural Logic Re-Wired” and “Computational Psychiatry”) to insights about the brain casting light on how we situate ourselves in this complex social world (“Making Everything Out of Nothing” and “Fashioning Community”), our writers paint a picture of a field rich with opportunities and unexplored connections. In addition to these topics, you will find in these pages rediscovery and innovation in medicine (“Ketamine’s Cinquecento” and “Seed-ation”), the arts (“Remedy in the Melody” and “Art of the Unconscious”), and our understanding of how romantic relationships can go awry (“Traces Found: Poison in Passion”).